Biostatistician • Data Scientist • Bioinformatician

Macarena Roel

Biostatistician and Statistical Programmer supporting decentralized clinical trials at Radicle Science and pediatric medical research at Hospital Garrahan. Passionate about reproducible science, evidence-based medicine, and bridging data science with clinical impact.

15+
Publications
5+
Years Research
200+
Students Taught

Turning clinical data into actionable evidence

I am a Bioinformatician by training who specialized in statistical programming and biostatistics through hands-on applied work. Currently I work as a Statistical Programmer at Radicle Science, supporting decentralized randomized clinical trials with reproducible workflows, and as a Research Collaborator at Hospital de Pediatria JP Garrahan in Buenos Aires, contributing biostatistical expertise to pediatric research.

My work spans systematic reviews, meta-analyses, longitudinal modeling, and clinical data pipelines. I am completing a Master's in Data Mining & Knowledge Discovery at Universidad de Buenos Aires, and I teach Biostatistics to biotech students.

R Stata Python SAS SQL Mixed-Effects Models Meta-Analysis Survival Analysis gtsummary ggplot2 Qualtrics BigQuery PROMIS Outcomes Reproducible Workflows
Sept 2024 -- Present
Radicle Science
Biostatistician & Statistical Programmer (Remote)
Decentralized clinical trials, PROMIS outcomes analysis, reproducible R/Python/Stata pipelines
Dec 2020 -- Present
Hospital Garrahan
Research Collaborator (Biostatistics), Buenos Aires
Pediatric infectious disease epidemiology, co-authored 15+ peer-reviewed publications
Aug 2022 -- Present
UADE
Biostatistics Lecturer, Buenos Aires
Undergraduate courses in Biostatistics for Biotechnology & Bioinformatics programs

Professional Experience

A trajectory bridging clinical research, biostatistics, and data science across academic and industry settings.

Biostatistician & Statistical Programmer

Radicle Science (Remote)
Sept 2024 -- Present
  • Develop and validate statistical analysis plans for decentralized randomized clinical trials
  • Automate data workflows in R and Python, reducing turnaround time and improving reproducibility
  • Lead migration of statistical workflows from Stata to R, modernizing infrastructure
  • Implement reproducible pipelines for trial datasets, improving transparency and audit-readiness

Research Collaborator (Biostatistics)

Hospital de Pediatria JP Garrahan, Buenos Aires
Dec 2020 -- Present
  • Apply advanced methods (longitudinal, survival, mixed-effects models) to pediatric and medical research
  • Co-author peer-reviewed publications in leading journals
  • Advise researchers on study design, sample size calculations, and analysis strategies

Biostatistics Lecturer

Universidad Argentina de la Empresa (UADE), Buenos Aires
Aug 2022 -- Present
  • Design and teach undergraduate Biostatistics courses for Biotechnology and Bioinformatics programs
  • Develop reproducible teaching materials and R-based exercises for 200+ students

Publications 15+ peer-reviewed

Selected peer-reviewed publications spanning pediatric infectious diseases, epidemiology, clinical outcomes, and surgical simulation.

2026
Antimicrobial stewardship programs in pediatric populations in Latin America and the Caribbean: A scoping review
Roel M, Ruvinsky S, et al.
Antibiotics (MDPI) -- submitted
2025
Burden and serotype distribution of invasive Pneumococcal disease among high-risk patients from Latin America and the Caribbean: A systematic review and meta-analysis
Bardach A, Ruvinsky S, et al. (incl. Roel M)
International Journal of Infectious Diseases
2025
Bidimensional shear wave spleen elastography for diagnosis and grading of esophageal varices in children with portal hypertension
Mackintosh C, Kaplan JS, Prati AY, Ruvinsky SD, Roel M, Bottero A, Dardanelli EP
Pediatric Radiology
2025
Second epidemiological study of pediatric sepsis and septic shock in Argentina (ESSPED-2)
Galvan ME, Viqueira Guzman C, Lanzavecchia E, Jabornisky R, Ruvinsky S, ..., Roel M, Vassallo JC
Archivos Argentinos de Pediatria
2025
Syphilis in a blood bank in Argentina: Prevalence trends and risk factors
Authors incl. Roel M
Transfusion Medicine
2024
Carbapenem-Resistant Enterobacteriaceae Bacteremia in Pediatric Patients in Latin America and the Caribbean: A Systematic Review and Meta-Analysis
Ruvinsky S, Voto C, Roel M, et al.
Antibiotics, 2024;13:1117
2024
Pediatric COVID-19 in Argentina: a comprehensive analysis of disease and economic burden through official data and a systematic literature review
Bardach A, Ruvinsky S, Moreno C, et al. (incl. Roel M)
Frontiers in Pediatrics, 2024;12:1352260
2024
Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
Sandoval MM, Ruvinsky S, Palermo MC, et al.
Frontiers in Public Health, 2024;12:1337276
2024
Nasopharyngeal carriage of Streptococcus pneumoniae in Latin America and the Caribbean: A systematic review and meta-analysis
Brizuela M, Palermo MC, Alconada T, Sandoval MM, Ramirez Wierzbicki E, Cantos J, Gagetti P, Ciapponi A, Bardach A, Ruvinsky S
PLoS One, 2024;19(5):e0297767
2023
Ultrasound attenuation imaging: a reproducible alternative for the noninvasive quantitative assessment of hepatic steatosis in children
Dardanelli EP, Orozco ME, Oliva V, et al. (incl. Ruvinsky S, Roel M)
Pediatric Radiology, 2023;53(8):1618-1628
2023
Results of training with a low-cost simulation model for endoscope-assisted scaphocephaly repair
Cuello JF, Gromadzyn G, Cicutti S, Roel M, Mantese B, Ruvinsky SD
Journal of Neurosurgery: Pediatrics, 2023;32(1):91-97
2023
Comparative effectiveness of telesimulation versus standard simulation for pediatric Minimally Invasive Surgery essential skills training
Falcioni AG, Yang HC, de Mattos E Silva E, Maricic MA, Ruvinsky S, Bailez MM
Journal of Pediatric Surgery, 2023;58(4):669-674
2022
Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis
Ruvinsky S, Voto C, Roel M, et al.
Frontiers in Pediatrics, 2022;10:881765
2022
Carbapenem-resistant Enterobacteriaceae bloodstream infections: A case-control study from a pediatric referral hospital in Argentina
Ruvinsky S, Voto C, Roel M, et al.
Frontiers in Public Health, 2022;10:983174

View full publication list on ResearchGate →

Academic Background

Combining bioinformatics foundations with advanced data science and clinical research training.

M.Sc. in Data Mining & Knowledge Discovery
Universidad de Buenos Aires
Mar 2021 -- Dec 2023
Thesis in progress. BeSmart Argentina Scholarship (2021).
B.Sc. in Bioinformatics
Universidad Argentina de la Empresa (UADE)
Mar 2015 -- Dec 2019
Fourth graduate of the Bioinformatics program.
Certifications & Training
Continuous learning
Introduction to Clinical Research (NIH, 2021) Human Research Protection Training SAS Programming for R Users (2023) SQL Intermediate (HackerRank, 2022) Python Data Analytics (EANT, 2021) Teaching, Learning & Innovation (ASU, 2024) Programa Internacional de Capacitacion Docente (ASU, 2023)

Academic Teaching

Building the next generation of data-literate biotech professionals.

Biostatistics

Lecturer, UADE (2022 -- Present)
  • Undergraduate courses for Biotechnology & Bioinformatics students
  • 200+ students per year
  • Reproducible R-based teaching materials and exercises
  • Topics: sampling distributions, parameter estimation, hypothesis testing, regression

Diplomatura en Investigacion e Innovacion Hospitalaria

Coordinator, Garrahan x UNSAM (2026)
  • First cohort of this postgraduate diploma (March -- August 2026)
  • 120 hours, fully virtual, three modules
  • Coordinating 23 faculty members
  • Topics: hospital-based research methods, innovation, translational research

Let's Connect

Open to research collaborations, consulting opportunities, and academic partnerships.